Methylene Blue is a synthetic compound that has been used in medicine for over a century, originally for diagnostic staining and treating methemoglobinemia. Recent scientific attention, however, has turned toward its potential neurocognitive benefits—suggesting that this once-humble dye may hold promise for enhancing memory, attention, and brain health.

Research suggests that Methylene Blue may support cognitive function by improving memory, attention, and executive performance. A study published in the journal Neurology reported that supplementation improved memory recall and recognition in older adults experiencing mild cognitive decline. Animal models also show that Methylene Blue can boost brain-derived neurotrophic factor (BDNF)—a critical protein involved in neuronal growth, learning, and plasticity.

In addition to its cognitive benefits, Methylene Blue has demonstrated neuroprotective properties. Studies indicate it can help safeguard neurons from oxidative stress and neuroinflammation—two major contributors to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. By minimizing oxidative damage and improving mitochondrial efficiency, Methylene Blue may help preserve cognitive function and slow the progression of age-related decline.

While the research on Methylene Blue is promising, it’s essential to consider dosage and safety. Like all pharmacological agents, higher doses can cause side effects such as headache, nausea, and urine discoloration. Individuals with certain medical conditions or those taking medications—particularly SSRIs or serotonergic agents—should consult a healthcare professional before use. Responsible dosing and medical supervision ensure that its benefits outweigh potential risks.