Targeted Relief • Prescription Required
Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
A specialized formulation that delivers Low-Dose Naltrexone (LDN) directly to vaginal tissue. This method provides localized immune modulation and is particularly helpful for chronic pelvic pain, lichen sclerosis, and other gynecological conditions linked to inflammation and immune dysregulation.
Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
Low-Dose Naltrexone (LDN) vaginal cream or gel is a compounded formulation designed for direct application to vaginal tissue, offering localized therapeutic effects. This targeted delivery ensures that LDN reaches the affected area efficiently while minimizing systemic exposure.
By reducing inflammation and modulating immune response, this therapy has shown benefits in managing conditions such as vulvodynia, pelvic inflammatory disease, lichen sclerosus, and atrophic vaginitis.
At Rock Ridge Pharmacy, each preparation is compounded in our USP <795> / <800> compliant lab, ensuring precise dosing, quality, and safety tailored to your provider’s prescription.
How Does Low-Dose Naltrexone (LDN) Vaginal Cream/Gel Work?
Localized Immune Modulation
When applied to vaginal tissue, LDN helps regulate local immune responses, supporting balance in conditions driven by inflammation and immune dysfunction.
Reduction of Inflammation
Direct application eases localized inflammation, reducing pain, irritation, and discomfort in pelvic and gynecological conditions.
Enhanced Symptom Relief
By concentrating treatment at the site of application, LDN vaginal cream/gel provides quicker and more targeted relief without significant systemic effects.
Conditions That Can Be Managed with Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
Chronic Vulvar Pain (Vulvodynia)
Provides localized pain relief and reduces inflammation directly in the affected tissue.
Lichen Sclerosus
Helps manage this chronic inflammatory skin disorder affecting the genital area, improving comfort and quality of life.
Pelvic Inflammatory Conditions
Used to alleviate chronic pelvic inflammation and related discomfort, targeting the affected tissues directly.
Atrophic Vaginitis
Especially useful for post-menopausal women, helping restore comfort and reduce irritation from vaginal atrophy.
Dosage Guidelines for Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
Personalized dosing ensures maximum benefit and safety, tailored to your condition and physician guidance.
Starting Concentration
Typically 1.5 mg to 2 mg per application, used once daily for initial therapy.
Dosage Adjustment
Doses may be adjusted based on patient symptom response, with higher concentrations used for more severe cases.
Frequency of Use
Typically applied once daily, though frequency may vary depending on physician recommendations and patient needs.
Supplements to Support LDN Therapy
When using Low-Dose Naltrexone (LDN) , certain supplements may improve tolerance, reduce side effects, and support immune balance.
- Omega-3 Fatty Acids – support anti-inflammatory balance and immune modulation
- Vitamin D₃ – helps regulate immune function and may enhance LDN’s benefits
- Magnesium Glycinate – promotes relaxation, sleep quality, and muscle comfort
- Probiotics – support gut health and balanced immune response
- Alpha-Lipoic Acid (ALA) – antioxidant that supports nerve health and reduces oxidative stress
Note: These supplements are supportive and not a replacement for LDN. Always consult your provider or pharmacist before starting new supplements.
Storage & Safety Information for Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
Proper storage and safe use of compounded LDN vaginal cream/gel ensures its effectiveness and patient comfort.
Storage Guidelines
Store compounded LDN vaginal cream/gel at 68°F–77°F (20°C–25°C) in a cool, dry place, away from direct heat and sunlight. Do not freeze unless instructed by your pharmacist. Always keep the medication in its original, labeled container with the cap tightly closed.
For safety, store out of reach of children and pets. If you notice any changes in texture, color, or odor, consult your pharmacist before use.
Questions about storage, expiration, or handling? Call (201) 444-4190 or email info@rockridgepharmacy.com.
Safety & Possible Side Effects
Common effects may include mild vaginal irritation, itching, or temporary discomfort at the application site. Short-term effects such as localized redness or dryness often resolve with continued use or dose adjustment. Rare reactions may include allergic responses or pelvic discomfort—report these to your provider immediately.
Disclaimer: This content is for educational purposes only and is not a substitute for medical advice. Always consult your healthcare provider before starting, changing, or discontinuing compounded LDN vaginal cream/gel therapy.
How Quickly Does Low-Dose Naltrexone (LDN) Work?
The onset of benefits depends on the condition being treated and individual patient response.
Autoimmune & Pain Conditions
For conditions like fibromyalgia, MS, or chronic pain, patients may notice improvements within 2–6 weeks, though steady benefits often build over several months.
Neurological & Mood Support
In cases of depression, PTSD, or neurological conditions, benefits may take several weeks to months, with gradual improvements as endorphin levels stabilize.
Key Takeaway
LDN works gradually and consistently. Close monitoring and open communication with your provider ensure dosing adjustments and the best long-term results.
Cost of Low-Dose Naltrexone (LDN) Vaginal Cream/Gel
Custom Compounding: LDN is prepared in personalized doses not available commercially, ensuring therapy tailored to your specific needs.
Affordable Pricing: Rock Ridge Pharmacy offers competitive pricing options, keeping LDN therapy accessible while maintaining the highest compounding standards.
Expert Guidance: Every prescription is compounded with precision and oversight from our pharmacists, who also provide ongoing support for dose adjustments, safety, and long-term use.
For details on custom LDN pricing, please call Rock Ridge Pharmacy at (201) 444-4190 or email info@rockridgepharmacy.com .
Is Low-Dose Naltrexone (LDN) Right for You?
Key considerations when evaluating whether LDN therapy may support your health needs.
Assess Your Condition
LDN is commonly used off-label for autoimmune conditions (MS, Crohn’s, Hashimoto's), chronic pain (fibromyalgia), and neurological disorders (Parkinson’s, Alzheimer’s). If you live with one of these, LDN may be worth exploring.
Consider Individual Variability
The effectiveness of LDN differs for each person. Factors such as overall health, severity of condition, and prior treatment responses influence results.
Monitor & Adjust Your Dose
LDN is usually started at 1.5 mg daily and increased gradually. Tracking symptoms and side effects helps find the optimal dose tailored to you.
Feedback & Risks
Stay in close contact with your healthcare provider to adjust treatment and monitor side effects. LDN is generally well-tolerated, with minor effects like vivid dreams or headaches balanced against potential benefits.
Disclaimer: This content is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting or adjusting LDN therapy.
Why Rock Ridge Pharmacy for Compounded LDN Vaginal Cream/Gel?
- Customized strengths — formulations typically range from 1.5 mg to 4.5 mg per dose, adjusted to your provider’s prescription.
- Precision compounding — prepared in our USP <795> & <800> compliant lab for purity, safety, and accuracy.
- Fast turnaround — most prescriptions ready within 24–48 hours across New Jersey.
Our compounding pharmacists carefully prepare each LDN vaginal cream or gel, ensuring consistent texture, potency, and absorption. Every formulation is verified to meet your provider’s therapeutic goals.
Patients also receive personalized pharmacist counseling — including guidance on safe application, expected effects, and managing potential side effects — to support effective, long-term use of LDN vaginal therapy.
FAQs about Low-Dose Naltrexone (LDN) Vaginal Cream
What is Low-Dose Naltrexone (LDN) Vaginal Cream/Gel and how is it compounded?
LDN vaginal cream/gel is a compounded medication that delivers naltrexone directly to vaginal tissues for targeted relief. At Rock Ridge Pharmacy, we prepare individualized strengths (typically 1.5–4.5 mg per dose) in our USP <795> / <800> compliant lab.
How does LDN vaginal cream/gel work?
When applied locally, LDN reduces inflammation, modulates the immune system, and eases pain in the vaginal and pelvic tissues. This provides concentrated relief while minimizing systemic side effects.
What conditions can LDN vaginal cream/gel help manage?
It may be prescribed for conditions such as lichen sclerosus, vulvodynia, atrophic vaginitis, and chronic pelvic pain syndromes.
Who is a good candidate for LDN vaginal therapy?
Patients with localized gynecological conditions, inflammatory pelvic disorders, or those who cannot tolerate oral LDN may benefit. Your provider will determine suitability.
How quickly can I expect results from LDN vaginal cream/gel?
Some patients notice symptom relief within 2–6 weeks. For others, consistent use over several months may be required for full benefit.
What is the typical dosage for LDN vaginal cream/gel?
Starting concentrations are often 1.5–2 mg per application, typically once daily. Dosage and frequency are adjusted by your provider based on your response.
How should I store LDN vaginal cream/gel?
Keep the medication at room temperature (68°F–77°F), away from heat and direct sunlight. Always store securely out of reach of children and pets.
Are there side effects with LDN vaginal cream/gel?
Most patients tolerate it well. Mild local irritation or temporary discomfort may occur. Serious side effects are rare but should be discussed with your provider.
Is LDN vaginal cream/gel safe for long-term use?
Yes, when monitored by your provider. Long-term use has been considered safe and is often necessary for chronic conditions.
Do I need a prescription for LDN vaginal cream/gel?
Yes. LDN vaginal cream/gel is a compounded medication and must be prescribed by a licensed provider.
How do Rock Ridge Pharmacy pharmacists support patients using LDN vaginal therapy?
Our pharmacists provide counseling on application technique, monitor for side effects, and collaborate with your prescriber to optimize treatment outcomes.
Get Started with Low-Dose Naltrexone (LDN) Vaginal Cream/Gel Today!
If you believe LDN vaginal cream or gel may benefit your condition, consult your healthcare provider and contact Rock Ridge Pharmacy. We specialize in customized compounding services, ensuring you receive the highest quality formulation tailored to your needs. Let us help you manage your condition with personalized care and expert guidance