Alternative Delivery • Prescription Required
Low-Dose Naltrexone (LDN) Suppositories
A specialized formulation designed for rectal or vaginal administration, providing an alternative route for localized treatment. This option is especially valuable for patients with gastrointestinal sensitivities or conditions requiring targeted immune modulation. At Rock Ridge Pharmacy, we prepare LDN suppositories using MBK (Mono- and Diglycerides of Fatty Acids), a non-irritating base recognized for its stability and effectiveness.
Low-Dose Naltrexone (LDN) Suppositories
Low-Dose Naltrexone (LDN) suppositories provide a unique and effective delivery method, designed for rectal or vaginal administration. This form ensures localized absorption through mucous membranes, improving access to the bloodstream or targeted tissues.
Suppositories are particularly beneficial for patients with gastrointestinal sensitivities, or those requiring direct immune modulation at specific sites. They are often used in managing chronic pain and autoimmune-related conditions where precision is key.
At Rock Ridge Pharmacy, we compound LDN suppositories using MBK (Mono- and Diglycerides of Fatty Acids), a non-irritating, stable base that enhances comfort, effectiveness, and consistency of treatment.
How Do Low-Dose Naltrexone (LDN) Suppositories Work?
Localized Absorption
LDN suppositories deliver medication directly through rectal or vaginal tissues, promoting efficient absorption and targeted immune modulation at the site of administration.
Concentrated Relief
This delivery method allows for concentrated treatment of conditions such as pelvic pain and inflammatory bowel disease while minimizing systemic exposure.
Alternative to Oral Therapy
Suppositories provide an effective alternative for patients with gastrointestinal sensitivities or difficulty swallowing pills, ensuring continued access to LDN therapy.
Key Benefits
• Localized treatment for pelvic pain and IBD
• Alternative for patients with GI sensitivities
• Enhanced absorption and effectiveness compared to oral therapy
Why Use MBK as a Base for Low-Dose Naltrexone (LDN) Suppositories?
At Rock Ridge Pharmacy, we use MBK (Mono- and Diglycerides of Fatty Acids), a gentle, non-irritating base, to compound LDN suppositories. MBK ensures that the suppository dissolves efficiently at body temperature, delivering the medication smoothly into the bloodstream or targeted tissues.
Non-Irritating
MBK is gentle on sensitive mucous membranes, making it well-suited for rectal or vaginal administration.
Stable
MBK maintains its shape and potency over time, ensuring consistency and reliability in every dose.
Efficient Absorption
Designed to melt smoothly at body temperature, MBK promotes rapid dissolution and effective absorption of LDN.
What Conditions Can Be Treated with Low-Dose Naltrexone (LDN) Suppositories?
Chronic Pain Syndromes
Suppositories provide targeted relief for pelvic pain and inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
Autoimmune Conditions
Beneficial for patients with localized immune dysfunction in the gastrointestinal or pelvic regions, offering a direct route for modulation.
Neurological Conditions
May help with immune modulation in neurological disorders such as multiple sclerosis and other chronic inflammatory conditions.
Dosage Guidelines for Low-Dose Naltrexone (LDN) Suppositories
Suppository dosing is personalized to each patient’s needs. Your provider will guide you through safe titration for optimal results.
Step 1: Starting Dose
Most patients begin with 1.5 mg daily to allow the body to adjust gradually to LDN therapy.
Step 2: Gradual Increase
The dose is usually increased by 0.5 mg every 1–2 weeks, based on tolerance and clinical response.
Step 3: Target Dose
Many patients stabilize between 3 mg and 4.5 mg daily, though the exact dose varies depending on individual needs and the treated condition.
Supplements to Support LDN Therapy
When using Low-Dose Naltrexone (LDN) , certain supplements may improve tolerance, reduce side effects, and support immune balance.
- Omega-3 Fatty Acids – support anti-inflammatory balance and immune modulation
- Vitamin D₃ – helps regulate immune function and may enhance LDN’s benefits
- Magnesium Glycinate – promotes relaxation, sleep quality, and muscle comfort
- Probiotics – support gut health and balanced immune response
- Alpha-Lipoic Acid (ALA) – antioxidant that supports nerve health and reduces oxidative stress
Note: These supplements are supportive and not a replacement for LDN. Always consult your provider or pharmacist before starting new supplements.
Storage & Safety Information for Low-Dose Naltrexone (LDN) Suppositories
Proper storage and safe administration of compounded LDN suppositories ensure effectiveness and minimize risks.
Storage Guidelines
Store compounded LDN suppositories in the refrigerator at 36°F–46°F (2°C–8°C) unless otherwise directed by your pharmacist. Keep them in their original, labeled container and avoid exposure to heat or direct sunlight, as suppositories may soften or melt.
Wash your hands before and after handling. Insert as directed by your prescriber. Always store out of reach of children and pets to prevent accidental use.
Questions about storage, expiration, or handling? Call (201) 444-4190 or email info@rockridgepharmacy.com.
Safety & Possible Side Effects
Common side effects may include mild rectal or vaginal irritation, temporary discomfort, or localized itching. Temporary effects such as minor cramping or bloating usually improve with continued use. Rare reactions such as significant irritation, swelling, or rash should be reported to your healthcare provider.
Disclaimer: This content is for educational purposes only and is not a substitute for medical advice. Always consult your healthcare provider before starting, changing, or discontinuing compounded LDN suppository therapy.
How Quickly Does Low-Dose Naltrexone (LDN) Work?
The onset of benefits depends on the condition being treated and individual patient response.
Autoimmune & Pain Conditions
For conditions like fibromyalgia, MS, or chronic pain, patients may notice improvements within 2–6 weeks, though steady benefits often build over several months.
Neurological & Mood Support
In cases of depression, PTSD, or neurological conditions, benefits may take several weeks to months, with gradual improvements as endorphin levels stabilize.
Key Takeaway
LDN works gradually and consistently. Close monitoring and open communication with your provider ensure dosing adjustments and the best long-term results.
Cost of Low-Dose Naltrexone (LDN) Suppositories
Custom Compounding: LDN is prepared in personalized doses not available commercially, ensuring therapy tailored to your specific needs.
Affordable Pricing: Rock Ridge Pharmacy offers competitive pricing options, keeping LDN therapy accessible while maintaining the highest compounding standards.
Expert Guidance: Every prescription is compounded with precision and oversight from our pharmacists, who also provide ongoing support for dose adjustments, safety, and long-term use.
For details on custom LDN pricing, please call Rock Ridge Pharmacy at (201) 444-4190 or email info@rockridgepharmacy.com .
Is Low-Dose Naltrexone (LDN) Right for You?
Key considerations when evaluating whether LDN therapy may support your health needs.
Assess Your Condition
LDN is commonly used off-label for autoimmune conditions (MS, Crohn’s, Hashimoto's), chronic pain (fibromyalgia), and neurological disorders (Parkinson’s, Alzheimer’s). If you live with one of these, LDN may be worth exploring.
Consider Individual Variability
The effectiveness of LDN differs for each person. Factors such as overall health, severity of condition, and prior treatment responses influence results.
Monitor & Adjust Your Dose
LDN is usually started at 1.5 mg daily and increased gradually. Tracking symptoms and side effects helps find the optimal dose tailored to you.
Feedback & Risks
Stay in close contact with your healthcare provider to adjust treatment and monitor side effects. LDN is generally well-tolerated, with minor effects like vivid dreams or headaches balanced against potential benefits.
Disclaimer: This content is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting or adjusting LDN therapy.
Why Rock Ridge Pharmacy for Compounded LDN Suppositories?
- Custom dosages — compounded to your provider’s prescription for individualized therapy.
- USP <795> & <800> compliant lab — ensuring consistency, quality, and patient safety.
- Specialized MBK base — a stable, non-irritating fatty acid base designed for smooth absorption and comfort.
Our compounding pharmacists carefully prepare each prescription of Low-Dose Naltrexone Suppositories, ensuring accurate dosing and proper formulation to maximize both absorption and patient tolerance.
Patients also receive personalized pharmacist support — from guidance on storage and administration to monitoring treatment response — helping ensure LDN suppository therapy is safe, effective, and tailored to your needs.
FAQs about Low-Dose Naltrexone (LDN) Suppositories
What are Low-Dose Naltrexone (LDN) Suppositories and how are they prepared?
LDN suppositories are compounded medications designed for rectal or vaginal administration. At Rock Ridge Pharmacy, we prepare them in custom strengths using MBK, a stable and non-irritating base for smooth absorption.
How do LDN Suppositories work?
Suppositories allow LDN to be absorbed through mucous membranes, promoting efficient delivery to the bloodstream or local tissues. This method supports targeted immune modulation and symptom relief.
What conditions can LDN Suppositories support?
They are often prescribed for pelvic pain, Crohn’s disease, ulcerative colitis, lichen sclerosus, multiple sclerosis, and other conditions where localized or alternative delivery is beneficial.
When will I start noticing results from LDN Suppositories?
Some patients notice improvements within 2–6 weeks, while maximum benefits may take up to 8–12 weeks depending on the condition and response.
How are LDN Suppositories administered?
Suppositories are inserted rectally or vaginally, usually once daily at bedtime, following your provider’s instructions.
What dosages are available for LDN Suppositories?
Typical compounded dosages range from 1.5 mg to 4.5 mg per suppository, but formulations can be customized to your provider’s prescription.
Can LDN Suppositories be used with oral medications?
Yes, but they should not be used with opioid medications. Always consult your provider or pharmacist before combining therapies.
What are the most common side effects of LDN Suppositories?
Mild side effects may include local irritation, discomfort, or changes in bowel habits. These effects are generally temporary and improve with continued use.
Are LDN Suppositories safe for long-term use?
Yes. LDN suppositories are considered safe for long-term therapy under provider supervision, particularly for chronic or localized conditions.
Do I need a prescription for LDN Suppositories?
Yes. LDN suppositories are compounded prescription medications and require a valid prescription from your healthcare provider.
How much do LDN Suppositories cost, and are they covered by insurance?
Pricing depends on dosage strength and quantity. Most insurance plans do not cover compounded LDN, but Rock Ridge Pharmacy provides affordable options.
How do Rock Ridge Pharmacy pharmacists support patients using LDN Suppositories?
Our pharmacists provide personalized counseling on administration, address side effects, and work closely with prescribers to optimize outcomes.
Where can I learn more about LDN research?
You can visit the LDN Research Trust or consult with our pharmacists for more resources.
Get Started with Low-Dose Naltrexone (LDN) Suppositories Today!
If you believe LDN suppositories may benefit your condition, contact Rock Ridge Pharmacy today to learn more. Our expert pharmacists will work closely with your healthcare provider to deliver the right customized care and ensure that your treatment is as effective as possible.