Potassium Bromide

Veterinary Compounding Medication – Customized for Dogs

Quick Reference

Common Uses: Controlling Seizures
Species: Dogs
Therapeutic Class: Antiepileptic

General Drug Information and Indications

Potassium bromide is an antiepileptic medication primarily used in dogs to control seizures when phenobarbital alone is not sufficient or tolerated. It reduces abnormal electrical activity in the central nervous system, helping stabilize seizure patterns and improve quality of life for affected dogs.

The drug’s full therapeutic effect may take up to four months to develop, and veterinarians may initiate treatment with a higher “loading dose” to reach effective blood levels faster—though this can increase the risk of temporary side effects.

Veterinary Medicine Uses

Potassium bromide plays a vital role in managing canine epilepsy, especially in cases where phenobarbital is ineffective or contraindicated due to liver health concerns. It requires consistent administration and long-term monitoring of blood bromide levels to maintain efficacy and minimize toxicity.

Because of its pharmacokinetics, owners must commit to routine veterinary visits for blood testing and dosage adjustments to ensure safe and stable seizure control.

How to Give This Medication

Administer potassium bromide exactly as prescribed by your veterinarian, preferably with food to reduce gastrointestinal irritation. Maintain a consistent dietary salt intake—sudden changes in sodium consumption can alter bromide levels and increase toxicity risk. Wash hands thoroughly after administration to prevent skin exposure.

Side Effects

During initial therapy or with loading doses, dogs may experience significant sedation. Other possible side effects include gastrointestinal irritation, increased thirst and urination, pancreatitis, and constipation. Older dogs may show heightened sensitivity or more frequent side effects.

Precautions

Use with caution in dogs with compromised kidney function, as the drug is excreted primarily through the kidneys. Potassium bromide should be used during pregnancy only when clearly necessary. Always store according to your pharmacist’s label instructions and keep out of reach of children and other pets.

Drug Interactions

Diuretics such as furosemide may accelerate potassium bromide excretion, reducing its therapeutic effect. Concurrent use with sedatives or tranquilizers can increase sedation. Always inform your veterinarian about all medications or supplements your pet is taking to prevent interactions.

Overdose and Toxicity Management

Chronic overdose can cause pronounced sedation, muscle pain, ataxia, or tremors due to elevated bromide levels. In suspected overdose or toxicity cases, contact your veterinarian or the Animal Poison Control Center immediately for emergency care and monitoring.

Custom Veterinary Compounding for Potassium Bromide

Rock Ridge Pharmacy offers precision-compounded Potassium Bromide formulations for dogs with epilepsy, ensuring individualized dosing and improved tolerability. Contact our veterinary compounding specialists to discuss formulation options, flavors, and dosage customization for your pet.

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