Clindamycin

Veterinary Compounding Medication – Customized for Dogs and Cats

Quick Reference

Basic Information

Clindamycin is a broad-spectrum lincosamide antibiotic that can act as either bacteriostatic or bactericidal depending on the concentration achieved at the infection site. It is well distributed throughout the body, penetrating bone, joints, and even the central nervous system when meningeal inflammation is present.

The drug is absorbed effectively when given orally and can be administered with food to improve gastrointestinal tolerance. Clindamycin is partially metabolized in the liver and excreted via urine, feces, and bile.

Indications

Administration Tips

Clindamycin should be given with food to reduce the risk of esophageal irritation and enhance gastrointestinal tolerance. Injectable forms should be monitored for localized discomfort at the injection site but are generally well tolerated.

Side Effects

Precautions

Use with caution in animals with severe hepatic or renal dysfunction, as dosage adjustments may be needed. Clindamycin can cross the placenta and is excreted in milk, occasionally causing diarrhea in nursing offspring.

Not recommended for horses or other herbivores due to the risk of severe diarrhea and potentially fatal Clostridial overgrowth.

Drug Interactions

Clindamycin may increase the effects of neuromuscular blocking agents and reduce cyclosporine levels. It should not be used concurrently with erythromycin or other macrolides, as antagonistic interactions may occur.

Overdose

Overdose incidents are rare since clindamycin has a broad safety margin. However, in the event of excessive ingestion, immediate veterinary evaluation is advised. Supportive care, including fluid therapy and symptomatic monitoring, may be necessary.