Apomorphine

Veterinary Compounding Medication – Primarily for Dogs (Rarely Used in Cats)

Quick Reference

Commonly Prescribed For: Inducing Vomiting

Species: Dogs and Rarely Cats

Therapeutic Class: D2-Dopamine-Receptor Agonist

Basic Information

Apomorphine HCl is a D2-dopamine-receptor agonist primarily used to induce vomiting in dogs, making it an essential emergency medication in cases of toxin ingestion. Unlike its parent compound, morphine, apomorphine does not provide pain relief; instead, it acts specifically on the brain’s chemoreceptor trigger zone to elicit an emetic response. Administration typically occurs under veterinary supervision in a clinical setting.

Veterinary Medicine Uses

Apomorphine activates dopamine receptors in the brain’s chemoreceptor trigger zone (CTZ), stimulating the vomiting center to induce emesis. It is most valuable in emergency scenarios where rapid expulsion of ingested toxins can prevent further absorption and systemic toxicity.

While it is highly effective in dogs, use in cats is rare due to a tendency to cause excitatory reactions rather than the desired emetic effect.

Potential Side Effects

Common: Temporary excitement, restlessness, or mild respiratory depression.

Less Common: Severe CNS depression or significant respiratory suppression, particularly if overdosed or in highly sensitive animals.

Precautions

Apomorphine should not be used in animals with hypersensitivity to the drug or in those experiencing seizures, respiratory distress, or unconsciousness. It should not be used when the ingested substance is corrosive, caustic, or petroleum-based, as vomiting can exacerbate injury. Repeated dosing is not advised if vomiting does not occur after initial administration, as it may lead to toxicity.

Drug Interactions

Veterinarians should evaluate all concurrent medications, as apomorphine may interact with sedatives, analgesics, or other dopamine-affecting drugs, leading to adverse neurological or respiratory effects. Due to its potent central nervous system activity, it must always be administered with veterinary oversight.

Custom Veterinary Compounding for Apomorphine

Rock Ridge Pharmacy provides professionally compounded Apomorphine formulations designed for precise dosing and safety. Contact our veterinary compounding specialists to learn more about emergency-use preparations and administration options.