Amitriptyline
Veterinary Compounding Medication – Customized for Dogs and Cats
Quick Reference
Basic Information
Amitriptyline is a tricyclic antidepressant (TCA) that affects serotonin and norepinephrine neurotransmission, helping to stabilize mood and behavior in animals. It also exhibits antihistaminic, anticholinergic, and sedative properties, making it versatile for managing behavioral and dermatologic issues in pets.
Uses in Dogs and Cats
Cats: Frequently prescribed to manage spraying or inappropriate elimination behaviors. It may also be used to treat anxiety linked to social stress or hierarchy issues. Additionally, amitriptyline can support cases of idiopathic feline urinary tract disease, though its success rate varies.
Dogs: Commonly used for separation anxiety, itching (pruritus), and neuropathic pain. Though clomipramine is typically preferred for separation anxiety, amitriptyline’s antihistamine effects make it beneficial as an adjunct therapy for pruritic dogs. It has also shown potential benefits for dogs with osteoarthritis-related discomfort.
Side Effects
Common: Sedation, constipation, and urinary retention.
Less common: Hyperexcitability, aggression, gastrointestinal upset, cardiac arrhythmias, ataxia (loss of coordination), or disorientation.
Precautions
Full therapeutic benefit may take 7–10 days. Sedation should be expected due to its antihistaminic effect. Amitriptyline may lower the seizure threshold and should be used cautiously in animals with seizure disorders. Avoid use during pregnancy unless benefits outweigh risks. Use with caution in pets with diabetes, liver or kidney impairment, glaucoma, or cardiac arrhythmias.
Drug Interactions
Amitriptyline may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), thyroid medications, CNS depressants, anticholinergic drugs, cimetidine, diazepam, and certain cardiac drugs. Concomitant use may heighten the risk of serotonin syndrome or excessive sedation.
Overdose
Overdose can result in severe cardiac arrhythmias, low blood pressure, and potential cardio-respiratory collapse. Immediate veterinary attention is critical. If ingestion is recent, gut-emptying protocols may be indicated, along with supportive care to stabilize cardiac rhythm and respiration.
Custom Veterinary Compounding for Amitriptyline
For customized veterinary formulations of Amitriptyline and other behavioral or pain management medications, trust Rock Ridge Pharmacy. Speak with our compounding team today to discuss dosage forms, strengths, and administration options for your pet.
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